Scientists have discovered for the first time that adult mouse brains produce new cells in the amygdala, a finding that could eventually lead to better treatments for conditions like anxiety and depression, as well as a better understanding of the brain overall.
The amygdala handles a lot of our emotional responses, especially those relating to fear, and broken connections inside it can lead to anxiety disorders such as post-traumatic stress disorder (PTSD).
If the brain is capable of regenerating neurons in the amygdala, then that’s potentially one way of fighting back against these mental health issues, according to the team from the University of Queensland in Australia.
“While it was previously known that new neurons are produced in the adult brain, excitingly this is the first time that new cells have been discovered in the amygdala,” says one of the team, Pankaj Sah from the Queensland Brain Institute.
“Our discovery has enormous implications for understanding the amygdala’s role in regulating fear and fearful memories.”
Before now, neurogenesis – the process of producing new neurons – had only been spotted in human adults in the hippocampus, the part of the brain that handles long-term memory and also deals with emotional responses, and the striatum.
Adult neurogenesis was first recognised in the 1960s, but was more widely accepted in the 1990s, thanks in part to the discovery of stem cells in adult mice brains – cells that can divide and develop into other types of cells.
That discovery was made by another team from the Queensland Brain Institute, and since then, scientists have confirmed the same process happens in humans.
Now it looks like it’s happening elsewhere too: based on new studies of mice, the researchers found evidence for the same stem cells in the amygdala, cells that could turn into genuine, fully functioning neurons. Now the task is to find the same results in humans.
Right now it’s not clear what those new neurons do, or how…