New research from Boston University School of Medicine (BUSM) provides evidence on the links between common mutations in blood cells and atherosclerosis in elderly patients.
The findings help shed light on why 60 percent of patients with atherosclerotic cardiovascular disease show no conventional risk factors, or have just one. Furthermore, the findings suggest that aging could just be one risk factor.
“Our studies show that mutations in our white blood cells, which we acquire as we age, may cause cardiovascular disease,” said study author Kenneth Walsh, PhD, a professor of medicine at BUSM, in a statement. “Understanding this new mechanism of cardiovascular disease could lead to the development of new therapies to treat individuals who suffer from heart and blood vessel ailments due to these mutations.”
Prior research shows that the accumulation of somatic DNA mutations is…