Blocking critical enzyme helps to mitigate diseases associated with … – Phys.Org

These images show a reduction in the number of macrophages infiltrating atherosclerotic plaques (in green) in animals treated with the IRE1 inhibitor. Credit: University of California – Santa Barbara

In the ancient Japanese art of origami, paper must be folded precisely and following a specific order to create the desired result—say, a crane or lotus flower. It’s a complex pursuit that requires keen attention to detail and utmost accuracy.

An equally precise biological process in living cells gives rise to proteins, the large biomolecules essential for life.

Proteins begin life as long strings of amino acids that must fold into the three-dimensional shape prescribed for their particular biological…

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