The game at the Emirates Stadium was overshadowed by a number of unsavoury incidents, most notably the banana skin thrown in the direction of Gunners striker Pierre-Emerick Aubameyang as he celebrated his side's opening goal.
Ozil has been criticised in the past for pulling out of games due to mystery back issues and it remains to be seen whether the former Real Madrid attacker will make himself available for selection for the trip to Old Trafford on Wednesday. Aaron Ramsey is capable of playing in a deeper midfield role but Emery seems to favour the Welshman further forward.
Harry Kane gave Spurs a 2-1 lead with a penalty of his own but second-half goals from Aubameyang, Alexandre Lacazette and Lucas Torreira secured victory for the hosts. Whether it is by accident or design is another matter.
For Tottenham, this was a third big game in nine days - following last weekend's victory over Chelsea and the midweek defeat of Inter Milan - and it felt like a bridge too far for exhausted players.
Ralph Hasenhuttl watching his new club struggle
With the Gunners facing the prospect of having to play nine games over a period of just four weeks, Ozil will be expected to adapt to Emery's new tactical approach or risk being left out of the squad altogether.
A miserable day for Tottenham was confounded by an 85th-minute red card awarded to Belgian defender Jan Vertonghen.
Eric Dier has admitted that losing to Arsenal in the North London derby hurt his team.
Ozil to miss Man United v Arsenal? five key things to know......
"Arsenal had a lot of energy but in the end it was even at 2-2 in the second half, the third goal was so tough for the team to come back again". Back spasms were also given as the reason when he missed October's win at Fulham.
Jurgen Klopp bristles at criticism of Liverpool midfielders ahead of Merseyside derby
This is a massive game for our city and we've been on the receiving end too many times". No, I don't see any problems in midfield '.