Mrs Trump was welcomed with a traditional dance at the Kotoka International Airport and ushered into the country officially by Ghana's First Lady Rebecca Akufo-Addo.
ABC News says its reporter Tom Llamas will interview Melania Trump during her trip to Africa for a "20/20" special to air October 12.
She took to twitter to say "Thank you #Ghana! They are simply taking advantage of their First Lady's high profile visit in Malawi to speak out so that the media here takes their message along as well", he said.
It was the first lady's second stop on a four-nation tour of the African continent.
"We see, first hand, in Malawian hospitals, the shocking effect the budget cuts may ultimately have". Later she visited another Chichewa classroom and laughed when a little boy stood up and, in English, proclaimed, "I am the best".
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The US First Lady laughed after one of the baby elephants made a sudden move and she momentarily lost her footing. The soccer balls, along with tote bags donated for the teachers, sported the logo of "Be Best", the child well-being initiative Mrs. Trump launched this year.
School educators also explained to the first lady how important the USAID textbook donations, which help power the country's National Reading Program, are to children at the school.
"I was heartened to spend time with the students and was honoured to donate school supplies and soccer balls", she said. "It is a lovely thing to see".
After the talks, Melania is scheduled to watch a performance by Sarakasi dancers at the Kenya National Theater.
The event was meant to "highlight friendly U.S. -Malawi relations" and the pair's "shared interest in helping children and, in particular, helping girls in school", according to the White House.