And on meeting the man who stands in his way to another US Open final, Nishikori said: "Yeah, always excited to play Novak because it's great challenge for me", said Nishikori.
Serbian sixth seed Djokovic, who will cap the night session, is in familiar territory, appearing in his 11th quarter-final at Flushing Meadows, and looks like a favourite with five-time victor Roger Federer knocked out of his half of the draw. Keys recorded her best result at a grand slam at last year's US Open when she finished runner-up to Sloane Stephens.
Upon missing a gimme volley - after Millman retrieved a lob with some incredibly scrambling - and then pushing a return wide, Djokovic staggered back into position before tipping water over his head at the changeover. I think she can win the title now.
"We were both struggling and trying to hang in there".
Japan's Nishikori, who missed last year's US Open after a season-ending wrist injury, joined compatriot Naomi Osaka in reaching the semis - the first time that a Japanese man and woman have reached the last four in the same grand slam.
"(We were) struggling at the end of the first set", he said.
Djokovic said after the match that he'd been "very tested", and paid full praise to his opponent after the 2 hour, 49 minute match.
This one wasn't exactly simple for Djokovic: He only converted four of 20 break points.
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Osaka wasn't born when compatriot Kimiko Date made the Wimbledon semi-finals in 1996 but now the 20-year-old has the opportunity to go one better by reaching a maiden Grand Slam final.
Next up is a mouth-watering clash against Argentine third seed Juan Martin del Potro and should Djokovic bag a third NY crown, he would join 14-times Grand Slam victor Pete Sampras in third on the all-time list, trailing only Roger Federer (20) and Rafael Nadal (17). The Serb saved five break points in the second game of the second set and he had to dig deep at 4-5 as well, fending off two set points in the game with seven deuces to level the score at 5-5. "Sorry", Osaka said after her quarterfinal victory.
It's another scorching hot day in NY and that means the extreme heat policy is back in effect for the third consecutive day at the U.S. Open.
He showed a resemblance of a fight in the third set, breaking Djokovic who double-faulted on the back of two serve-time violations.
She pushed some balls a few feet past the baseline, often failing to make Osaka do anything special to win a point and finishing with 31 unforced errors.
He goes on to play Japan's Kei Nishikori in the last four on Friday.
The hot and humid conditions, which left Federer out of breath, took their toll on Djokovic who looked sluggish early in the second set.
Once again, however, the Australian was broken at 4-4, upon which Djokovic served out to love to complete his victory.
Suarez celebrated her 30th birthday with a victory over five-time Grand Slam victor Maria Sharapova on Monday.