After Sami Khedira lost possession, Javier Hernandez triggered a lightning counter before finding a charging Lozano, who cut inside a covering Ozil and lashed low inside Neuer's near post to spark deafening roars from the sizeable Mexico support.
"It's great to start on the right foot when you're playing against the world champions". Supporters could be heard yelling "puto" - the Spanish word for a male prostitute - when Manuel Neuer prepared to take a goal kick in the 24th minute of Sunday's Group F game.
France in 2002 and Spain in 2014 were the other defending champions to lose their opening matches. Three of the past four have failed to make it out of the group stage.
Germany, meanwhile, had 26 shots without causing Guillermo Ochoa too many problems, although the Mexico goalkeeper made nine saves in keeping a memorable clean sheet.
SIMMSA, the "seismic monitoring network" from the Institute of Geological and Atmospheric Research, is reporting that tremors were detected in Mexico City during the country's World Cup match against Germany on Sunday.
"The game against Saudi Arabia was actually a wake-up call". Germany created plenty of chances, with Joshua Kimmich, in particular, proving a threat down the right-hand side, but Mexico were full value for their lead at the break.
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Henley was the only player to reach 3 under at any point, and he promptly gave that back with a double bogey on No. 10. McIlroy found trouble just about everywhere and shot 80, his highest first-round score in a major.
Lozano's goal at the Luzhniki Stadium earned Mexico just the second win over Germany in history, as Loew's side paid the price for a dismal first half.
"What happened hey, what happened hey, to the Germany that was going to beat us today?" the crowd chanted.
It means Mexico celebrated its goal so hard that it created its own quake.
Mexico pulled back into a more defensive formation midway through the second half as key players exhausted and had to withstand heavy pressure from Germany. Germany then dominated but when it broke through the Mexican defence, the shooting was poor.
Coach Juan Carlos Osorio's bold approach - often leaving three attackers up the pitch even when defending set-pieces - paid off, as celebrating fans in Mexico City caused a minor quake. Even though Germany outshot Mexico 25-12, had 61 percent possession and completed 519 passes to Mexico's 224, El Tri was the most risky team for much of the night. Coach Juan Carlos Osorio and the players have stated they are up to the challenge and are not afraid.
Mexico, the perennial underachievers, who so often arrive at big tournaments on a wave of optimism only to crash out at the first hurdle, began the game with a bang.