Ingram, who set career highs by rushing for 1,124 yards and 12 touchdowns last season, will not be eligible to rejoin the team's active roster until October 1.
New Orleans opens its season with home games against the Buccaneers and Browns, then has a pair of road games against the Falcons and Giants.
Kamara rushed for 728 yards and eight touchdowns, averaging 6.1 yards per carry, and also amassed 81 receptions for five more scores in his rookie campaign.
Despite the suspension, Ingram will still be allowed to participate in everything the Saints do this offseason, which means he'll be at training camp and he'll be allowed to play in each of the team's four preseason games.
Ballsy! Snooker world champ fulfills promise and attends presser naked
He led 10-7 overnight and soon stretched that to 14-7, Higgins potting just 31 points over the four frames. Williams has now promised to perform "naked cartwheels" if he manages to defend his world title next year.
According to ESPN's Darren Rovell, the four-game suspension will cost Ingram $941,176.
In the meantime, second-year pro Alvin Kamara will take on an even bigger role in the Saints offense after being named NFL Offensive Rookie of the Year. "This is also why New Orleans hasn't shopped him".
Ingram, 28, was the Saints' first-round pick (28th overall) in the 2011 NFL draft out of Alabama, where he won the Heisman Trophy in 2009 and helped the Crimson Tide win the national championship. The Saints also have Trey Edmunds, Jonathan Williams and Daniel Lasco in the backfield to go along with former Louisiana Tech running back Boston Scott, who was selected in the sixth round of this year's draft. The Week 2 trip to New Orleans comes when the host Saints will be without starting running back Mark Ingram.
He is a two-time Pro Bowl selection (2014, 2017) and has 5,362 career rushing yards and 44 rushing touchdowns.