Khan was brutally knocked out by Saul "Canelo" Alvarez in Las Vegas when he stepped up to middleweight in May 2016.
Brook was convinced straight away that Khan does not in fact want the fight, whereas Khan insisted he does and that he is chasing Brook after signing with the same promoter as him - Eddie Hearn.
Sky Sports Main Event will also pick up the action from 9.45pm United Kingdom time, with Khan vs Lo Greco predicted to start at around 10pm, depending on how the undercard plays out - more on that in a bit.
His opponent tonight is a live underdog, Phil Lo Greco an Italian-Canadian boxer who got under Khan's skin at the fight announcement press conference when he mentioned the wife of Khan, it ticked Khan off so much he threw a glass of water in his face.
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Sky Sports has the rights to tonight's Khan vs Lo Greco fight and will be kicking off coverage on its new-look Sky Sports Action channel at 7pm BST.
Whether, after almost two years out of competitive action, he still has the speed and technique to shield his fragile chin is the question fight fans will want answered.
"I have been out the ring for two years but I was still in the gym working hard, I have never taken a day off". I'm not going to say he's a bad fighter, he's a very good fighter, and he won a world title, so you have to respect that. I'm here, I want the fight. Kell Brook has been making a living off my name for a long, long time. I am a stronger fighter, a better fighter. I would like to be in a stadium to be honest with you. That fight I'm not rushing and I'm not running away from. "Stylistically, I've got a 100 per cent record against southpaws", said Khan, a former world champion at super-lightweight.
But an unimpressed Brook said: "He doesn't want the fight, he just ran off".