The attack killed at least 14 people, seven of them were reported to be Iranian nationals.
Syrian state media SANA reported "several missiles" had hit the T-4 base in central Syria just before dawn on Monday. This is the same airbase that Israel attacked in February, in which one of its planes was shot down.
Though there has been some mention of the alleged Saturday chemical weapons attack in Douma, Israel has largely not focused on that as a justification for their attacks in Syria.
According to the Russian military, the strikes were carried out from Lebanese airspace.
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"By striking the base once again, Israel sends the message that Russia simply can not ignore this trend, both because of the risks it implies, and because Russian and Iranian soldiers are physically working a few feet away from each other", he said.
Five out of eight strikes, carried out by the Israeli F-15 jets, were destroyed by Syrian air defenses, the ministry said. "Three missiles reached the western part of the airfield. There are no Russian [military] advisers among those injured".
But even as Israel was being criticized for the raid, some security officials have been calling for a more aggressive approach in Syria aimed at preventing Iran and its proxy militia Hezbollah from expanding their influence there and their ability to menace Israel. "In the fight against the terrorists, who have disrupted unity and stability in the region, Tehran supports the Syrian government and will continue to maintain strategic ties with the country", added Velayati, a Farsi report by Qods News Agency said. Thousands of rebels and their families have been moved out.