He's being rested by coach Zidane for the first time in the league this season.
Madrid lie a whopping 17 points behind LaLiga leaders Barcelona and, with their title hopes effectively over, can afford to focus their attentions on their campaign to lift a third successive Champions League trophy.
Marcelo picked up a hamstring problem against Real Betis on Sunday, meaning Theo Hernandez is likely to be handed a rare start at left-back, while both Luka Modric (hamstring) and Toni Kroos (knee) are out. However, the form of Marco Asensio and Lucas Vazquez means Bale's starting spot is under threat once more.
After kocking out Los Blancos, the capital club saw their Copa del Rey run end at the hands of Sevilla in the semi-finals and have since lost their last two games in the Primera Division: 1-0 at home to Eibar and 3-0 at Girona.
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Leganes versus Real Madrid kicks off at the unusual time of 18:45 local time on Wednesday in order to avoid a clash with the Champions League fixtures on the same night.
According to The Sun's Helen Rowe-Willcocks, Leganes will be without Darko Brasanac and Jon Ander Serantes as both are nursing shoulder injuries, but Alexander Szymanowski and Mauro dos Santos could feature, having returned to training following issues of their own.
Gareth Bale has new competition at Real Madrid.
And either side of that they hit five goals in domestic wins over Real Socieded and Real Betis.